American Trans Air flies directly between the following airports.
| Departing: | Arriving: |
| Albuquerque International Airport (ABQ), Albuquerque NM, United States | Logan (BOS), Boston MA, United States |
| Reina Beatrix Airport (AUA), Aruba, Netherlands Antilles | Midway Airport (MDW), Chicago IL, United States |
| Hartford - Bradley International Airport (BDL), Windsor Locks CT, United States | Midway Airport (MDW), Chicago IL, United States |
| Birmingham Airport (BHM), Birmingham AL, United States | Midway Airport (MDW), Chicago IL, United States |
| Nashville Airport (BNA), Nashville TN, United States | Midway Airport (MDW), Chicago IL, United States |
| Logan (BOS), Boston MA, United States | Albuquerque International Airport (ABQ), Albuquerque NM, United States |
| Logan (BOS), Boston MA, United States | Midway Airport (MDW), Chicago IL, United States |
| Baltimore Washington International (BWI), Washington DC, United States | Midway Airport (MDW), Chicago IL, United States |
| Cleveland - Hopkins International Airport (CLE), Cleveland OH, United States | Midway Airport (MDW), Chicago IL, United States |
| Port Columbus International Airport (CMH), Columbus OH, United States | Midway Airport (MDW), Chicago IL, United States |
| Cancun (CUN), Cancun, Mexico | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Cancun (CUN), Cancun, Mexico | Midway Airport (MDW), Chicago IL, United States |
| Cozumel Airport (CZM), Cozumel, Mexico | Midway Airport (MDW), Chicago IL, United States |
| Ronald Reagan National Airport (DCA), Washington DC, United States | Midway Airport (MDW), Chicago IL, United States |
| Denver Airport (DEN), Denver CO, United States | Midway Airport (MDW), Chicago IL, United States |
| Dallas (DFW), Fort Worth TX, United States | San Francisco (SFO), San Francisco CA, United States |
| Dallas (DFW), Fort Worth TX, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Dallas (DFW), Fort Worth TX, United States | Midway Airport (MDW), Chicago IL, United States |
| Wayne County Airport (DTW), Detroit MI, United States | Midway Airport (MDW), Chicago IL, United States |
| Dress Regional Airport (EVV), Evansville IN, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| New York Newark (EWR), Newark NJ, United States | Midway Airport (MDW), Chicago IL, United States |
| Fort Lauderdale Airport (FLL), Fort Lauderdale FL, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Fort Lauderdale Airport (FLL), Fort Lauderdale FL, United States | Midway Airport (MDW), Chicago IL, United States |
| Bishop Airport (FNT), Flint MI, United States | Midway Airport (MDW), Chicago IL, United States |
| Bishop Airport (FNT), Flint MI, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Municipal/baer Field (FWA), Fort Wayne IN, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Miguel Hidal Airport (GDL), Guadalajara, Mexico | Midway Airport (MDW), Chicago IL, United States |
| Kent County International Airport (GRR), Grand Rapids MI, United States | Midway Airport (MDW), Chicago IL, United States |
| Chicago Regional Airport (GYY), Gary IN, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Honolulu Airport (HNL), Honolulu HI, United States | Midway Airport (MDW), Chicago IL, United States |
| Houston - Hobby Airport (HOU), Houston TX, United States | Midway Airport (MDW), Chicago IL, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Los Angeles (LAX), Los Angeles CA, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Kahului Airport (OGG), Kahului HI, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Municipal/baer Field (FWA), Fort Wayne IN, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Fort Lauderdale Airport (FLL), Fort Lauderdale FL, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Fort Myers Regional (RSW), Fort Myers, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Midway Airport (MDW), Chicago IL, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Dallas (DFW), Fort Worth TX, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Dress Regional Airport (EVV), Evansville IN, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Bishop Airport (FNT), Flint MI, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | La Guardia Airport (LGA), New York NY, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Orlando (MCO), Orlando FL, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Las Vegas - Mccaran International Airport (LAS), Las Vegas NV, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Chicago Regional Airport (GYY), Gary IN, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | South Bend Regional Airport (SBN), South Bend IN, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Bradenton Airport (SRQ), Sarasota FL, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Sky Harbor International Airport (PHX), Phoenix AZ, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Cancun (CUN), Cancun, Mexico |
| Indianapolis International Airport (IND), Indianapolis IN, United States | St Petersburg/Clearwater Intl (PIE), St Petersburg/Clearwater, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | Milwaukee Airport (MKE), Milwaukee WI, United States |
| Indianapolis International Airport (IND), Indianapolis IN, United States | San Juan (SJU), San Juan, Puerto Rico |
| Indianapolis International Airport (IND), Indianapolis IN, United States | San Francisco (SFO), San Francisco CA, United States |
| Long Island Macarthur Airport (ISP), Islip NY, United States | Midway Airport (MDW), Chicago IL, United States |
| Jackson Ms Airport (JAN), Jackson MS, United States | Midway Airport (MDW), Chicago IL, United States |
| Las Vegas - Mccaran International Airport (LAS), Las Vegas NV, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Las Vegas - Mccaran International Airport (LAS), Las Vegas NV, United States | Midway Airport (MDW), Chicago IL, United States |
| Las Vegas - Mccaran International Airport (LAS), Las Vegas NV, United States | Los Angeles (LAX), Los Angeles CA, United States |
| Los Angeles (LAX), Los Angeles CA, United States | Orlando (MCO), Orlando FL, United States |
| Los Angeles (LAX), Los Angeles CA, United States | Midway Airport (MDW), Chicago IL, United States |
| Los Angeles (LAX), Los Angeles CA, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Los Angeles (LAX), Los Angeles CA, United States | Las Vegas - Mccaran International Airport (LAS), Las Vegas NV, United States |
| La Guardia Airport (LGA), New York NY, United States | Midway Airport (MDW), Chicago IL, United States |
| La Guardia Airport (LGA), New York NY, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Little Rock Regional Airport (LIT), Little Rock AR, United States | Midway Airport (MDW), Chicago IL, United States |
| Kansas City International International Airport (MCI), Kansas City MO, United States | Midway Airport (MDW), Chicago IL, United States |
| Orlando (MCO), Orlando FL, United States | Los Angeles (LAX), Los Angeles CA, United States |
| Orlando (MCO), Orlando FL, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Orlando (MCO), Orlando FL, United States | Midway Airport (MDW), Chicago IL, United States |
| Midway Airport (MDW), Chicago IL, United States | St Paul International Airport (MSP), Minneapolis MN, United States |
| Midway Airport (MDW), Chicago IL, United States | Dallas (DFW), Fort Worth TX, United States |
| Midway Airport (MDW), Chicago IL, United States | Bishop Airport (FNT), Flint MI, United States |
| Midway Airport (MDW), Chicago IL, United States | Kent County International Airport (GRR), Grand Rapids MI, United States |
| Midway Airport (MDW), Chicago IL, United States | Honolulu Airport (HNL), Honolulu HI, United States |
| Midway Airport (MDW), Chicago IL, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Midway Airport (MDW), Chicago IL, United States | Jackson Ms Airport (JAN), Jackson MS, United States |
| Midway Airport (MDW), Chicago IL, United States | Kansas City International International Airport (MCI), Kansas City MO, United States |
| Midway Airport (MDW), Chicago IL, United States | Little Rock Regional Airport (LIT), Little Rock AR, United States |
| Midway Airport (MDW), Chicago IL, United States | Los Angeles (LAX), Los Angeles CA, United States |
| Midway Airport (MDW), Chicago IL, United States | Standiford Field (SDF), Louisville KY, United States |
| Midway Airport (MDW), Chicago IL, United States | Nashville Airport (BNA), Nashville TN, United States |
| Midway Airport (MDW), Chicago IL, United States | Cozumel Airport (CZM), Cozumel, Mexico |
| Midway Airport (MDW), Chicago IL, United States | Logan (BOS), Boston MA, United States |
| Midway Airport (MDW), Chicago IL, United States | La Guardia Airport (LGA), New York NY, United States |
| Midway Airport (MDW), Chicago IL, United States | New York Newark (EWR), Newark NJ, United States |
| Midway Airport (MDW), Chicago IL, United States | Ronald Reagan National Airport (DCA), Washington DC, United States |
| Midway Airport (MDW), Chicago IL, United States | Reina Beatrix Airport (AUA), Aruba, Netherlands Antilles |
| Midway Airport (MDW), Chicago IL, United States | Midway Airport (MDW), Chicago IL, United States |
| Midway Airport (MDW), Chicago IL, United States | Baltimore Washington International (BWI), Washington DC, United States |
| Midway Airport (MDW), Chicago IL, United States | Denver Airport (DEN), Denver CO, United States |
| Midway Airport (MDW), Chicago IL, United States | Durham/raleigh Airport (RDU), Raleigh/Durham NC, United States |
| Midway Airport (MDW), Chicago IL, United States | Las Vegas - Mccaran International Airport (LAS), Las Vegas NV, United States |
| Midway Airport (MDW), Chicago IL, United States | San Francisco (SFO), San Francisco CA, United States |
| Midway Airport (MDW), Chicago IL, United States | Birmingham Airport (BHM), Birmingham AL, United States |
| Midway Airport (MDW), Chicago IL, United States | Metropolitan Oak International Airport (OAK), Oakland CA, United States |
| Midway Airport (MDW), Chicago IL, United States | Omaha Airport (OMA), Omaha NE, United States |
| Midway Airport (MDW), Chicago IL, United States | Manchester Municipal Airport (MHT), Manchester NH, United States |
| Midway Airport (MDW), Chicago IL, United States | Port Columbus International Airport (CMH), Columbus OH, United States |
| Midway Airport (MDW), Chicago IL, United States | Orlando (MCO), Orlando FL, United States |
| Midway Airport (MDW), Chicago IL, United States | Cleveland - Hopkins International Airport (CLE), Cleveland OH, United States |
| Midway Airport (MDW), Chicago IL, United States | Wayne County Airport (DTW), Detroit MI, United States |
| Midway Airport (MDW), Chicago IL, United States | Fort Lauderdale Airport (FLL), Fort Lauderdale FL, United States |
| Midway Airport (MDW), Chicago IL, United States | Miguel Hidal Airport (GDL), Guadalajara, Mexico |
| Midway Airport (MDW), Chicago IL, United States | Long Island Macarthur Airport (ISP), Islip NY, United States |
| Midway Airport (MDW), Chicago IL, United States | Tampa International (TPA), Tampa, United States |
| Midway Airport (MDW), Chicago IL, United States | Houston - Hobby Airport (HOU), Houston TX, United States |
| Midway Airport (MDW), Chicago IL, United States | Theodore Francis Airport (PVD), Providence RI, United States |
| Midway Airport (MDW), Chicago IL, United States | Philadelphia (PHL), Philadelphia PA, United States |
| Midway Airport (MDW), Chicago IL, United States | Hartford - Bradley International Airport (BDL), Windsor Locks CT, United States |
| Midway Airport (MDW), Chicago IL, United States | Bradenton Airport (SRQ), Sarasota FL, United States |
| Midway Airport (MDW), Chicago IL, United States | Seattle/tacoma International Airport (SEA), Seattle WA, United States |
| Midway Airport (MDW), Chicago IL, United States | Saint Louis Airport (STL), St Louis MO, United States |
| Midway Airport (MDW), Chicago IL, United States | St Petersburg/Clearwater Intl (PIE), St Petersburg/Clearwater, United States |
| Midway Airport (MDW), Chicago IL, United States | South Bend Regional Airport (SBN), South Bend IN, United States |
| Midway Airport (MDW), Chicago IL, United States | Cancun (CUN), Cancun, Mexico |
| Midway Airport (MDW), Chicago IL, United States | San Diego Airport (SAN), San Diego CA, United States |
| Midway Airport (MDW), Chicago IL, United States | Sky Harbor International Airport (PHX), Phoenix AZ, United States |
| Midway Airport (MDW), Chicago IL, United States | Fort Myers Regional (RSW), Fort Myers, United States |
| Manchester Municipal Airport (MHT), Manchester NH, United States | Midway Airport (MDW), Chicago IL, United States |
| Milwaukee Airport (MKE), Milwaukee WI, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| St Paul International Airport (MSP), Minneapolis MN, United States | Midway Airport (MDW), Chicago IL, United States |
| Metropolitan Oak International Airport (OAK), Oakland CA, United States | Midway Airport (MDW), Chicago IL, United States |
| Kahului Airport (OGG), Kahului HI, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Omaha Airport (OMA), Omaha NE, United States | Midway Airport (MDW), Chicago IL, United States |
| Philadelphia (PHL), Philadelphia PA, United States | Midway Airport (MDW), Chicago IL, United States |
| Sky Harbor International Airport (PHX), Phoenix AZ, United States | Midway Airport (MDW), Chicago IL, United States |
| Sky Harbor International Airport (PHX), Phoenix AZ, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| St Petersburg/Clearwater Intl (PIE), St Petersburg/Clearwater, United States | Midway Airport (MDW), Chicago IL, United States |
| St Petersburg/Clearwater Intl (PIE), St Petersburg/Clearwater, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Theodore Francis Airport (PVD), Providence RI, United States | Midway Airport (MDW), Chicago IL, United States |
| Durham/raleigh Airport (RDU), Raleigh/Durham NC, United States | Midway Airport (MDW), Chicago IL, United States |
| Fort Myers Regional (RSW), Fort Myers, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Fort Myers Regional (RSW), Fort Myers, United States | Midway Airport (MDW), Chicago IL, United States |
| San Diego Airport (SAN), San Diego CA, United States | Midway Airport (MDW), Chicago IL, United States |
| South Bend Regional Airport (SBN), South Bend IN, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| South Bend Regional Airport (SBN), South Bend IN, United States | Midway Airport (MDW), Chicago IL, United States |
| Standiford Field (SDF), Louisville KY, United States | Midway Airport (MDW), Chicago IL, United States |
| Seattle/tacoma International Airport (SEA), Seattle WA, United States | Midway Airport (MDW), Chicago IL, United States |
| San Francisco (SFO), San Francisco CA, United States | Dallas (DFW), Fort Worth TX, United States |
| San Francisco (SFO), San Francisco CA, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| San Francisco (SFO), San Francisco CA, United States | Midway Airport (MDW), Chicago IL, United States |
| San Juan (SJU), San Juan, Puerto Rico | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Bradenton Airport (SRQ), Sarasota FL, United States | Midway Airport (MDW), Chicago IL, United States |
| Bradenton Airport (SRQ), Sarasota FL, United States | Indianapolis International Airport (IND), Indianapolis IN, United States |
| Saint Louis Airport (STL), St Louis MO, United States | Midway Airport (MDW), Chicago IL, United States |
| Tampa International (TPA), Tampa, United States | Midway Airport (MDW), Chicago IL, United States |
